Comment on: “Wnt Binding Affinity Prediction for Putative Frizzled-Type Cysteine-Rich Domains”
نویسندگان
چکیده
منابع مشابه
Cysteine-rich domains related to Frizzled receptors and Hedgehog-interacting proteins.
Frizzled and Smoothened are homologous seven-transmembrane proteins functioning in the Wnt and Hedgehog signaling pathways, respectively. They harbor an extracellular cysteine-rich domain (FZ-CRD), a mobile evolutionary unit that has been found in a number of other metazoan proteins and Frizzled-like proteins in Dictyostelium. Domains distantly related to FZ-CRDs, in Hedgehog-interacting protei...
متن کاملThe cysteine-rich frizzled domain of Frzb-1 is required and sufficient for modulation of Wnt signaling.
Convincing evidence has accumulated to identify the Frizzled proteins as receptors for the Wnt growth factors. In parallel, a number of secreted frizzled-like proteins with a conserved N-terminal frizzled motif have been identified. One of these proteins, Frzb-1, binds Wnt-1 and Xwnt-8 proteins and antagonizes Xwnt-8 signaling in Xenopus embryos. Here we report that Frzb-1 blocks Wnt-1 induced ...
متن کاملResponse to the comment on 'protein-protein binding affinity prediction from amino acid sequence'
MOTIVATION Protein-protein interactions play crucial roles in many biological processes and are responsible for smooth functioning of the machinery in living organisms. Predicting the binding affinity of protein-protein complexes provides deep insights to understand the recognition mechanism and identify the strong binding partners in protein-protein interaction networks. RESULTS In this work...
متن کاملPutative DHHC-Cysteine-Rich Domain S-Acyltransferase in Plants
Protein S-acyltransferases (PATs) containing Asp-His-His-Cys within a Cys-rich domain (DHHC-CRD) are polytopic transmembrane proteins that are found in eukaryotic cells and mediate the S-acylation of target proteins. S-acylation is an important secondary and reversible modification that regulates the membrane association, trafficking and function of target proteins. However, little is known abo...
متن کاملWnt - Frizzled Signaling via Cyclic
1. Abstract 2. Atypical, non-canonical pathways of Wnt-Frizzled signaling 3. Frizzled-2 as a G-protein-coupled receptor 4 Discovery of Gt alpha (transducin) expression in embryonic cells 5. Inhibition of Frizzled-2 signaling by inhibitors of cyclic GMP phosphodiesterase 6. Frizzled-2 regulates intracellular concentration of cyclic GMP 7. Inhibition of cyclic GMP phosphodiesterases blocks develo...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2019
ISSN: 1422-0067
DOI: 10.3390/ijms20194884